Oxidative stress and sperm chromatin damage in male infertility
نویسندگان
چکیده
منابع مشابه
Oxidative stress and sperm chromatin damage in male infertility.
Researchers studying the causes of male infertility have recently focused on the role played by reactive oxygen species (ROS)—a highly reactive oxidizing agent belonging to the class of free radicals. ROS are produced by a variety of semen components, and antioxidants in the seminal fluid keep their levels in check. Small amounts of ROS help spermatozoa acquire their necessary fertilizing capab...
متن کاملClinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis.
Oxidative stress (OS) in the reproductive tract is now a real entity and concern due to the potential harmful effects of high levels of reactive oxygen species (ROS) on sperm number, motility, quality, and function including damage to sperm nuclear DNA. Evaluation of OS related damage to non-functional sperm is highly relevant as intracytoplasmic sperm injection (ICSI) technique, an effective t...
متن کاملOxidative stress & male infertility.
The male factor is considered a major contributory factor to infertility. Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a new and important cause has been identified: oxidative stress. Oxidative stress is a result of the imbalance between reactive oxygen species (ROS) and antiox...
متن کاملOxidative stress induced sperm DNA damage, a possible reason for male infertility
BACKGROUND Sperm DNA damage is an important factor in the etiology of male infertility. OBJECTIVE The aim of the study was to evaluate the association of oxidative stress induced sperm DNA damage with the pathogenesis of male infertility. MATERIALS AND METHODS The study comprised a total of 66 subjects, including fertile men (n=25) and infertile men (n=41) matched by age. Seminal malondiald...
متن کاملRole of sperm chromatin abnormalities and DNA damage in male infertility.
Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a highly compact and complex structure and is capable of decondensation-features that must be present in order for a spermatozoon to be considered fertile. Any form of sperm chromatin abnormalities or DNA damage may result in male infertility. In support of this conclusion, it was reported that in-vivo...
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ژورنال
عنوان ژورنال: International braz j urol
سال: 2007
ISSN: 1677-5538
DOI: 10.1590/s1677-55382007000500001